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The results showed that overexpression of -Syn and the formation of oligomers have cytotoxic effects, upregulate local inflammatory markers, induce LC fiber degeneration, disrupt striatal dopamine metabolism, and exacerbate non-motor behaviors in PD

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In the Sibutramine Cardiovascular Outcomes (SCOUT) trial, the drug was shown to be associated with increased risk of major adverse cardiovascular events (a composite of non-fatal heart attack, non-fatal stroke, resuscitation after cardiac arrest, and cardiovascular death) in obese patients, as compared to placebo [29]

Kedar PS, Warang P, Ghosh K, Colah RB

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Clinical and reference strains of C